---
title: "Prescription Heroine (S20E16) | familyguy.co.uk"
canonical: "https://familyguy.co.uk/episodes/s20e16-prescription-heroine/"
updatedDate: 2026-09-06
author: Alex Moss
description: "Prescription Heroine: Family Guy season 20 episode 16 (S20E16), first aired 27 March 2022. Writer and director credits."
---

# Prescription Heroine

Episode 16 of Family Guy season 20 (S20E16), the 385th Family Guy episode overall. Written by Emily Towers and directed by Joseph Lee. First broadcast on 27 March 2022.

## Story

Brian breaks his arm barking at a delivery man, and Lois takes to his painkillers. When the bottle runs out she goes looking for more, and an attempt that nearly drowns Stewie leads Brian to shut her in his crate until the drugs wear off. She gives the pills up, keeping only the music that went with them. In the second story, Cleveland saves Peter's old table tennis table from the tip and mends it, and it draws the neighbours in. Peter, envious, is told he cannot simply take it back, so the two play for it and destroy it, which suits Cleveland, who had tired of the visitors.

## Facts

| Fact | Detail |
| --- | --- |
| Season | 20 |
| Episode | 16 of 20 |
| Overall | No. 385 |
| Code | S20E16 |
| First aired | 27 March 2022 |
| Directed by | Joseph Lee |
| Written by | Emily Towers |
| Source | Wikipedia: Family Guy season 20 |
| Wikidata | Q111263094 |
| IMDb | tt18394906 |
| Verification | Checked against Wikidata and IMDb: title, date, numbering and credits agree |
| US viewers | 1.13 million |

## Voices

| Voice | Characters |
| --- | --- |
| Seth MacFarlane | Peter Griffin, Brian Griffin, Stewie Griffin |
| Alex Borstein | Lois Griffin |
| Seth Green | Chris Griffin |
| Mila Kunis | Meg Griffin |
| Patrick Warburton | Joe Swanson |
| Arif Zahir | Cleveland Brown |
| Stephanie Beatriz | Esperanza |
| H. Jon Benjamin | Carl |
| Travis Bowe | Cocky Jogger |

Principal voice credits as recorded by IMDb, which lists up to ten credits per episode, so recurring characters can be missing here. Guest voices below come from Wikipedia and TVmaze.

## Links

- Season: [20](https://familyguy.co.uk/episodes/season-20/)
- Source: [Wikipedia: Family Guy season 20](https://en.wikipedia.org/wiki/Family_Guy_season_20)
- Wikidata: [Q111263094](https://www.wikidata.org/wiki/Q111263094)
- IMDb: [tt18394906](https://www.imdb.com/title/tt18394906/)
- US viewers: [1.13 million](https://en.wikipedia.org/wiki/Family_Guy_season_20)

## Navigation

- Previous: [S20E15 Hard Boiled Meg](https://familyguy.co.uk/episodes/s20e15-hard-boiled-meg/)
- Next: [S20E17 All About Alana](https://familyguy.co.uk/episodes/s20e17-all-about-alana/)
- Season hub: [Season 20](https://familyguy.co.uk/episodes/season-20/)
- All episodes: [Family Guy episode guide](https://familyguy.co.uk/episodes/)

## Season 20: episode 16 of 20

- S20E01 [LASIK Instinct](https://familyguy.co.uk/episodes/s20e01-lasik-instinct/)
- S20E02 [Rock Hard](https://familyguy.co.uk/episodes/s20e02-rock-hard/)
- S20E03 [Must Love Dogs](https://familyguy.co.uk/episodes/s20e03-must-love-dogs/)
- S20E04 [80's Guy](https://familyguy.co.uk/episodes/s20e04-80s-guy/)
- S20E05 [Brief Encounter](https://familyguy.co.uk/episodes/s20e05-brief-encounter/)
- S20E06 [Cootie & The Blowhard](https://familyguy.co.uk/episodes/s20e06-cootie-and-the-blowhard/)
- S20E07 [Peterschmidt Manor](https://familyguy.co.uk/episodes/s20e07-peterschmidt-manor/)
- S20E08 [The Birthday Bootlegger](https://familyguy.co.uk/episodes/s20e08-the-birthday-bootlegger/)
- S20E09 [The Fatman Always Rings Twice](https://familyguy.co.uk/episodes/s20e09-the-fatman-always-rings-twice/)
- S20E10 [Christmas Crime](https://familyguy.co.uk/episodes/s20e10-christmas-crime/)
- S20E11 [Mister Act](https://familyguy.co.uk/episodes/s20e11-mister-act/)
- S20E12 [The Lois Quagmire](https://familyguy.co.uk/episodes/s20e12-the-lois-quagmire/)
- S20E13 [Lawyer Guy](https://familyguy.co.uk/episodes/s20e13-lawyer-guy/)
- S20E14 [HBO-No](https://familyguy.co.uk/episodes/s20e14-hbo-no/)
- S20E15 [Hard Boiled Meg](https://familyguy.co.uk/episodes/s20e15-hard-boiled-meg/)
- S20E16 Prescription Heroine (this entry)
- S20E17 [All About Alana](https://familyguy.co.uk/episodes/s20e17-all-about-alana/)
- S20E18 [Girlfriend, Eh?](https://familyguy.co.uk/episodes/s20e18-girlfriend-eh/)
- S20E19 [First Blood](https://familyguy.co.uk/episodes/s20e19-first-blood/)
- S20E20 [Jersey Bore](https://familyguy.co.uk/episodes/s20e20-jersey-bore/)

---

Unofficial fan resource. Not affiliated with, endorsed by, or sponsored by FOX, Disney, or Fuzzy Door Productions.