Season 6 · Episode 5 · First aired 11 November 2007

Lois Kills Stewie

Episode 5 of Family Guy season 6 (S06E05), the 103rd Family Guy episode overall. Written by Steve Callaghan and directed by Greg Colton. First broadcast on 11 November 2007.

Story

Lois tells the courtroom how she survived: a reverse merman rescued her, she lost her memory and worked at a fat camp in North Carolina, and a blow to the head at a white supremacist rally restored it. Stewie flees the courthouse, ties up his family, kills Cleveland and makes Brian drive him to CIA headquarters in Langley Falls. Chris frees the others and they find Stewie's armoury. At the CIA Stewie seizes a supercomputer and the global power grid, meets Stan Smith and Avery Bullock, and is declared President of the World. He imposes harsh laws. Lois arms herself from his vault and fights him in the Oval Office, gaining the upper hand but unable to kill her own child. Peter shoots Stewie first. Brian then finds Stewie stepping out of a simulator: the sequence was a test of what might happen, and he decides he is not ready.

Production and reception

Steve Callaghan wrote the episode and Greg Colton directed it; the pair had previously worked together on the season five episode "Whistle While Your Wife Works". Wikipedia, Stewie Kills Lois and Lois Kills Stewie
Patrick Stewart and Phil LaMarr guest starred. The American Idol panel of Randy Jackson, Paula Abdul and Simon Cowell also appeared, voting Stewie out of an audition in a cutaway. Wikipedia, Stewie Kills Lois and Lois Kills Stewie
When Stewie hacks the supercomputer he meets Avery Bullock and Stan Smith of American Dad!; the Volume 6 DVD extends the crossover with an earlier encounter in a toilet. Wikipedia, Stewie Kills Lois and Lois Kills Stewie
20th Century Fox issued the two-parter on the Volume 6 DVD, which reached the United States and Canada on 21 October 2008. Wikipedia, Stewie Kills Lois and Lois Kills Stewie
Ahsan Haque of IGN rated it 9.4 out of 10, and Richard Keller of TV Squad reviewed it more warmly than the first part while finding the ending predictable. Wikipedia, Stewie Kills Lois and Lois Kills Stewie

Voices

Voice	Characters
Seth MacFarlane	Peter Griffin, Brian Griffin, Stewie Griffin
Alex Borstein	Lois Griffin
Seth Green	Chris Griffin
Mila Kunis	Meg Griffin
Mike Henry	Cleveland Brown, Bruce the Performance Artist, Consuela
Paula Abdul	Paula Abdul
David Boat	Rupert
Alexandra Breckenridge	Katie Holmes, Hilary Swank
Simon Cowell	Simon Cowell
Mark Hentemann	Audience Member, Painter

Principal voice credits as recorded by IMDb, which lists up to ten credits per episode, so recurring characters can be missing here. Guest voices below come from Wikipedia and TVmaze.

Guest voices

Patrick Stewart as Avery Bullock
Paula Abdul as herself
Randy Jackson as himself
Simon Cowell as himself
Patrick Warburton as Joe Swanson
Adam West as Mayor Adam West
Mike Henry as Consuela
Phil LaMarr as Judge

Season 6: episode 5 of 12

Season hub with air dates and credits for all 12 episodes

SourceFacts from Wikipedia: Family Guy season 6 and the episode's article (CC BY-SA 4.0). Spotted an error? See corrections.

Provenance

Facts only

Sources: Wikipedia: Lois Kills Stewie
Wikipedia: Stewie Kills Lois and Lois Kills Stewie
Wikidata Q4043136
IMDb
TVmaze
Data refreshed: 6 September 2026
Verification: Checked against Wikidata and IMDb: Wikidata differs on director
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Licence: Facts are not copyrightable. Source text on Wikipedia is CC BY-SA 4.0; Wikidata is CC0; IMDb data is used for verification under its non-commercial terms.
Note: The story summary and notes were written for this site from the sources listed, by Claude in Claude Code on 2026-09-08, awaiting editorial review. Facts only; no dialogue is reproduced. Voice credits: Information courtesy of IMDb (https://www.imdb.com). Used with permission. Guest cast data from TVmaze (https://www.tvmaze.com), CC BY-SA.