familyguy.co.ukUnofficial
fan encyclopedia

Season 20 · Episode 16 · First aired 27 March 2022

Prescription Heroine

Episode 16 of Family Guy season 20 (S20E16), the 385th Family Guy episode overall. Written by Emily Towers and directed by Joseph Lee. First broadcast on 27 March 2022.

Story

Brian breaks his arm barking at a delivery man, and Lois takes to his painkillers. When the bottle runs out she goes looking for more, and an attempt that nearly drowns Stewie leads Brian to shut her in his crate until the drugs wear off. She gives the pills up, keeping only the music that went with them. In the second story, Cleveland saves Peter's old table tennis table from the tip and mends it, and it draws the neighbours in. Peter, envious, is told he cannot simply take it back, so the two play for it and destroy it, which suits Cleveland, who had tired of the visitors.

Voices

VoiceCharacters
Seth MacFarlanePeter Griffin, Brian Griffin, Stewie Griffin
Alex BorsteinLois Griffin
Seth GreenChris Griffin
Mila KunisMeg Griffin
Patrick WarburtonJoe Swanson
Arif ZahirCleveland Brown
Stephanie BeatrizEsperanza
H. Jon BenjaminCarl
Travis BoweCocky Jogger

Principal voice credits as recorded by IMDb, which lists up to ten credits per episode, so recurring characters can be missing here. Guest voices below come from Wikipedia and TVmaze.

Season 20: episode 16 of 20

  1. E1LASIK Instinct
  2. E2Rock Hard
  3. E3Must Love Dogs
  4. E480's Guy
  5. E5Brief Encounter
  6. E6Cootie & The Blowhard
  7. E7Peterschmidt Manor
  8. E8The Birthday Bootlegger
  9. E9The Fatman Always Rings Twice
  10. E10Christmas Crime
  11. E11Mister Act
  12. E12The Lois Quagmire
  13. E13Lawyer Guy
  14. E14HBO-No
  15. E15Hard Boiled Meg
  16. E16Prescription HeroineYou are here
  17. E17All About Alana
  18. E18Girlfriend, Eh?
  19. E19First Blood
  20. E20Jersey Bore

Season hub with air dates and credits for all 20 episodes

SourceFacts from Wikipedia: Family Guy season 20 (CC BY-SA 4.0). Spotted an error? See corrections.

Provenance

Facts only
Data refreshed
6 September 2026
Verification
Checked against Wikidata and IMDb: title, date, numbering and credits agree
This page as
Markdown, JSON-LD, or request it with Accept: text/markdown
Licence
Facts are not copyrightable. Source text on Wikipedia is CC BY-SA 4.0; Wikidata is CC0; IMDb data is used for verification under its non-commercial terms.
Note
The story summary and notes were written for this site from the sources listed, by Claude in Claude Code on 2026-09-08, awaiting editorial review. Facts only; no dialogue is reproduced. Voice credits: Information courtesy of IMDb (https://www.imdb.com). Used with permission.