Season 20 · Episode 16 · First aired 27 March 2022
Prescription Heroine
Episode 16 of Family Guy season 20 (S20E16), the 385th Family Guy episode overall. Written by Emily Towers and directed by Joseph Lee. First broadcast on 27 March 2022.
Story
Brian breaks his arm barking at a delivery man, and Lois takes to his painkillers. When the bottle runs out she goes looking for more, and an attempt that nearly drowns Stewie leads Brian to shut her in his crate until the drugs wear off. She gives the pills up, keeping only the music that went with them. In the second story, Cleveland saves Peter's old table tennis table from the tip and mends it, and it draws the neighbours in. Peter, envious, is told he cannot simply take it back, so the two play for it and destroy it, which suits Cleveland, who had tired of the visitors.
Voices
| Voice | Characters |
|---|---|
| Seth MacFarlane | Peter Griffin, Brian Griffin, Stewie Griffin |
| Alex Borstein | Lois Griffin |
| Seth Green | Chris Griffin |
| Mila Kunis | Meg Griffin |
| Patrick Warburton | Joe Swanson |
| Arif Zahir | Cleveland Brown |
| Stephanie Beatriz | Esperanza |
| H. Jon Benjamin | Carl |
| Travis Bowe | Cocky Jogger |
Principal voice credits as recorded by IMDb, which lists up to ten credits per episode, so recurring characters can be missing here. Guest voices below come from Wikipedia and TVmaze.
Season 20: episode 16 of 20
- E1LASIK Instinct
- E2Rock Hard
- E3Must Love Dogs
- E480's Guy
- E5Brief Encounter
- E6Cootie & The Blowhard
- E7Peterschmidt Manor
- E8The Birthday Bootlegger
- E9The Fatman Always Rings Twice
- E10Christmas Crime
- E11Mister Act
- E12The Lois Quagmire
- E13Lawyer Guy
- E14HBO-No
- E15Hard Boiled Meg
- E16Prescription HeroineYou are here
- E17All About Alana
- E18Girlfriend, Eh?
- E19First Blood
- E20Jersey Bore
SourceFacts from Wikipedia: Family Guy season 20 (CC BY-SA 4.0). Spotted an error? See corrections.
Provenance
Facts only- Data refreshed
- 6 September 2026
- Verification
- Checked against Wikidata and IMDb: title, date, numbering and credits agree
- Licence
- Facts are not copyrightable. Source text on Wikipedia is CC BY-SA 4.0; Wikidata is CC0; IMDb data is used for verification under its non-commercial terms.
- Note
- The story summary and notes were written for this site from the sources listed, by Claude in Claude Code on 2026-09-08, awaiting editorial review. Facts only; no dialogue is reproduced. Voice credits: Information courtesy of IMDb (https://www.imdb.com). Used with permission.